'Tis but a scratch: a critical review of the Women's Health Initiative evidence associating menopausal hormone therapy with the risk of breast cancer
In sum, findings generated by the WHI to date warrant the following conclusions:
1. CEE (Conjugated Estrogen) alone significantly reduces breast cancer risk and breast
cancer mortality.
2. CEE+MPA, when initiated in HT naïve women, does not increase breast cancer risk and does not increase breast cancer mortality, even for women with a family history of breast cancer.
3. Even if the WHI estimate of an increased risk of breast cancer is accepted based on the elevated HR, a result driven solely by allow incidence of breast cancer in the placebo group, CEE+MPA would be responsible for less than 1 additional nonfatal breast cancer diagnosis for every 1,000 women treated.
4. No estimate of an association between CEE+MPA and breast cancer remains statistically significant with per-protocol adjustment.
* I provide this current analysis by Dr. Blooming and Hodis which updates the flawed Women’s Health Initiative study of the 2000s. They describe flaws of this study and summarize current data that shows HRT is safe
* EVOKE HRT: uses ONLY bioidentical HRT- NOT synthetic HRT in optimizing hormones- estrodiol and progesterone- none of which have shown increased cancer risks in any studies.
